Lactobacillus rhamnosus GG Associated with Increased Necrotizing Enterocolitis in Observational Study

A recent retrospective study (AF Kane et al. J Pediatr 2018; 195: 73-9) with 640 VLBW infants found that the probiobiotic, Lactobacillus rhamnosus GG (LGG), was associated with an increased risk of necrotizing enterocolitis (NEC).

LGG supplementation was started at a median age of 6 days at a dose of 2.5 to 5 x 10 to the 9th CFU/day.

Key finding:

  • LGG group had an aOR of 2.10 for developing NEC.  LGG group NEC incidence was 16.8% whereas NEC incidence was 10.2% prior to institution of LGG.

The authors note their findings are in contrast to findings from 38 randomized trials (10,520) which have found that probiotics lowered the risk of NEC.

My take: This study reinforces the need for further studies to identify which factors and probiotic strains are likely to lead to reduced rates of NEC.

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5 thoughts on “Lactobacillus rhamnosus GG Associated with Increased Necrotizing Enterocolitis in Observational Study

  1. Your title is not correct—if you read the article and title of the official article it did not INCREASE the risk of NEC there was no difference in the rate and no side effects to it’s use.

  2. Pingback: Is CMV a Trigger for Necrotizing Enterocolitis? | gutsandgrowth

  3. Pingback: Probiotics in Preemies: Lifesaving Therapy | gutsandgrowth

  4. Pingback: Can Necrotizing Enterocolitis Be Prevented with Antibiotics? | gutsandgrowth

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