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High Rates of Helicobacter Pylori Resistance

June 17, 2013 6:24 am

While the development of antibacterial resistance has broad implications, in gastroenterology patients specific problems have emerged with Helicobacter pylori (H pylori) and this has led to changes in first-line therapy( ).  More data on the treatment resistant H pylori has been published (JPGN 2013; 56: 645-48).

77 consecutive strains of H pylori  from Brazilian children and adolescents were isolated from gastric biopsies and analyzed; this study took place between 2008-2009 and the mean age was 11.1 years.  In 71 strains, there were no previous attempts at eradication.

Results:

• 40% of strains were resistant to metronidazole
• 19.5% of strains were resistant to clarithromycin
• 10.4% of strains were resistant to amoxicillin
• All strains were susceptible to furazolidone and tetracycline
• 14/77 (18.2%) patients had multiple resistances

Take-home point: Resistance to antibiotics is altering our approach to H pylori therapy.  Antibiotic susceptibility testing may be needed to improve antibiotic selection and eradication rates.

Related blog links:

• Helicobacter pylori –useful advice | gutsandgrowth
• Preventing lethal antibiotic resistant outbreaks | gutsandgrowth
• Antibiotic resistance: doomed to repeat | gutsandgrowth
• Sugar-resistant bugs | gutsandgrowth

Posted by gutsandgrowth

Categories: Pediatric Gastroenterology Intestinal Disorder

Tags: amoxicillin, antibiotic resistance, clarithromycin, Helicobacter pylori, metronidazole, tetracycline

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5 Responses to “High Rates of Helicobacter Pylori Resistance”

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