Using a UK National registry with 106,013 children, investigators determined that there was no overall risk of cancer among children born after assisted conception during a 17-year study period (NEJM 2013; 369; 1819-27).

Among individual cancers, this cohort had an increased risk of hepatoblastoma and rhadomyosarcoma, though the absolute risk was quite low.  The risks for these cancers may be related to chance or indirectly related to parental infertility through mechanisms like low birth weight or imprinting disorders.