Briefly noted: Necrotizing Enterocolitis After Onasemnogen Abeparvovec for Spinal Muscular Atrophy

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J Gaillard et al. J Pediatr 2023; 260: 113493. Necrotizing Enterocolitis following Onasemnogene Abeparvovec for Spinal Muscular Atrophy: A Case Series

Background: Onasemnogene abeparvovec treats spinal muscular atrophy by delivering a functional SMN1 gene.

Key finding: This case report documents two cases of medically-treated necrotizing enterocolitis (NEC) that developed shortly after Onasemnogen Abeparvovec which was administered at ~3 weeks of life in two full term infants (born at 40 and 41 weeks).

My take: Consider the diagnosis of NEC in full term infants with SMA who have received gene therapy.

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While grabbing a snack & taking a break from our bike ride, we saw all of these wind surfers. The wind on this day was crazy and these surfers looked like they were going 30-40 mph