Recently, this blog post reviewed a case presentation of hereditary angioedema which often presents with bouts of severe abdominal pain: “A Swell Diagnosis”

Now, a study has shown how this can be effectively treated with CRISPR gene editing:

• HJ Longhurst et al. N Engl J Med 2024; 390:432-441. CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema.

My take: Gene therapies have been very expensive. If this therapy is approved for hereditary angioedema it will be too. However, some of the current treatments for preventing hereditary angioedema are also quite costly.

Related blog posts:

• “A Swell Diagnosis”
• Overlooking Important Detail$ in Hereditary Angioedema Treatment
• Intermittent Abdominal Pain and Intestinal Swelling –a Mystery? This case highlights how some medications (eg. lisinopril) can trigger angioedema