CLMP stands for Coxsackie- and adenovirus receptor-like membrane protein. It is required for intestinal development (Gastroenterology 2012; 142: 453-62).

In this study of seven patients from five families with congenital short-bowel syndrome (SBS), the authors identified a loss-of-function of CLMP in five of the patients.  CLMP is a tight-junction-associated protein that is expressed in the intestine of human embryos throughout development.

To study the effect of CLMP expression, the authors created a zebrafish model with compromised CLMP activity.  This lead to offspring with a foreshortened body and intestine, strengthening the evidence that CLMP dysfunction is responsible for congenital short-bowel syndrome.

Additional references/previous related posts:

• Four advances for intestinal failure
• PNAC, PNALD, and IFAC
• -Can J Gastroenterol. 2008 January; 22(1): 71–74. Case report of congenital short bowel.
• -Indian J Radiol Imaging. 2010 August; 20(3): 227–229. Case report of congenital short bowel.