CLMP stands for Coxsackie- and adenovirus receptor-like membrane protein. It is required for intestinal development (Gastroenterology 2012; 142: 453-62).
In this study of seven patients from five families with congenital short-bowel syndrome (SBS), the authors identified a loss-of-function of CLMP in five of the patients. CLMP is a tight-junction-associated protein that is expressed in the intestine of human embryos throughout development.
To study the effect of CLMP expression, the authors created a zebrafish model with compromised CLMP activity. This lead to offspring with a foreshortened body and intestine, strengthening the evidence that CLMP dysfunction is responsible for congenital short-bowel syndrome.
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