In a previous post (HAV vaccination: how long will it take?), it was noted that U.S. HAV immunization rates are poor but much better in states that have employed a strategy of implementing universal vaccination for a longer period. Another article provides reassurance that once patients are vaccinated that the immunity is quite durable (Hepatology 2012; 56: 516-22).
197 infants and children were followed after HAV immunization; these patients were divided into three groups; two dose immunization at 6 & 12 months (group 1), at 12 & 18 months (group 2), and at 15 & 21 months(group 3). Anti-HAV serology was followed sequentially. At 10 years, almost all children retained seroprotection (>10 mIU/mL) levels, >95% of group 2 & 3. In group 1, 7% of infants born to anti-HAV negative mothers and 11% of infants born to anti-HAV positive mothers did not have protective antibody levels.
Conclusion: Seropositivity for HAV persists for at least 10 years after vaccination with two-dose regimen when administered to children 12 months of age and older.
Something to think about (unrelated to blog post):
A Zen master was once asked, “What is the key to happiness?”
He answered, “Good judgment.”
“How do I gain good judgment?” he was questioned.
“Experience,” was the reply.
“How then do I get experience?” the student further probed.
“Bad judgment,” were his final words.
(quoted previously in Pediatrics and from the following link QUOTATIONS AND PASSAGES ON EXPERIENCE)