How to dissolve a bezoar

Some bezoars, like lactobezoars, can resolve quite easily often with intravenous fluids.  Trichobezoars often require surgery.  Phytobezoars can dissolve with  diet coke and cellulase (Gastroenterol Hepatol 2012; 8: 770-72).

A phytobezoar, which is the most common type, is composed of indigestible fruit and vegetable fibers and occur in the setting of impaired gastric motility.  In the three cases presented, the combination of diet coke and an over-the-counter cellulase (Enzymedica Digest Gold) which contains 3000 units of cellulase per capsule was successful at dissolution of the phytobezoars over a 6-8 week period.

The role of the diet coke is less certain.  The sodium bicarbonate in sodas and the penetration of carbon dioxide bubbles may have facilitated dissolution.  Additionally, the acidic pH (2.6) of Coca-Cola along with the phosphoric and carbonic acids may have been beneficial.  While Coca-Cola and Diet Coke have the same potential mechanism of action, Diet Coke is easier to administer in diabetic patients.

Additional references:

2 thoughts on “How to dissolve a bezoar

  1. thank you for the info very helpful. This is one of the reasons the internet is so great.
    But you mention sodium bicarbonate which is alkaline material and not found in coke products. Other articles refer to the phosphoric acid in colas to be the other helpful ingredient along with the carbonic acids as you mention. I have started this treatment and have found great relieve within the first two hours.
    thank you

  2. Pingback: Popular Posts 2015 | gutsandgrowth

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