A summary of the effectiveness of polyethylene glycol for chronic constipation, fecal disimpaction, and as a bowel preparation are presented in a recent article (JPGN 2013; 57: 134-40).
The article provides information on the biochemistry and mechanism of action along with a good number of references –49.
From the summary:
“PEG is an osmotic laxative used in children in the last few years. It is more effective than lactulose for the treatment of chronic constipation. It is equally effective compared with milk of magnesia and mineral oil for the long-term treatment of constipation but has a much better acceptance rate…It is a safe medication without any significant adverse effects. Because PEG can be mixed in a beverage of the patient’s choice, it has excellent long-term patient acceptance.”
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