Cognitive Outcomes after Liver Transplantation

An important measure of liver transplantation (LT) is cognitive/academic outcomes. Previous studies have indicated increased intellectual deficits but were not optimally-designed.  A recent study (J Pediatr 2014; 165: 65-72) overcomes many of the limitations of previous studies.

Study design: Prospective, multicenter longitudinal cohort of neurocognitive functioning after pediatric liver transplantation.  144 participants, ≥2 years after liver transplantation -recruited through Studies of Pediatric Liver Transplantation (SPLIT).  Tested with multiple cognitive test at two separate time points.

Key findings:

  • At the time 2, 29% had full scale IQ (FSIQ) between 71-85 (compared to 14% expected); 7% had FSIQ <71 (compared with 2% expected)
  • 42% received special education.
  • Pretransplant markers of nutritional status and operative complications predicted intellectual outcome
  • Having a primary care provider with a college education was a protective factor.

One limitation of the study was that only 55% of those approached to participate were enrolled; however, the authors noted similar demographics between those who enrolled and those who did not.

2 thoughts on “Cognitive Outcomes after Liver Transplantation

  1. Pingback: Intellectual Disability in Pediatric Liver Transplantation | gutsandgrowth

  2. Pingback: What to Expect After Pediatric Liver Transplantation: Cognitive Function and Quality of Life | gutsandgrowth

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.