Reducing Diagnostic Uncertainty in Hirschsprung’s Disease

Previously this blog noted the emergence of calretinin immunohistochemisty (What is calretinin? | gutsandgrowth).  Now, more data has been published indicating that calretinin reduces inconclusive rectal biopsies for the diagnosis of Hirschsprung’s disease (JPGN 2014; 58: 603-07).

The authors analyzed data retrospectively for 45 patients prior to the use of calretinin and 42 patients after calretinin introduction.

Key finding: 37.8% (17 of 45) of patients had inconclusive rectal biopsies prior to use of calretinin compared with 11.9% (5 of 42) after including calretinin immunohistochemistry.

2 thoughts on “Reducing Diagnostic Uncertainty in Hirschsprung’s Disease

  1. Pingback: “Genetic Testing and the Future of Pediatric Gastroenterology” | gutsandgrowth

  2. Pingback: Rectal Suction Biopsies Less Accurate in Infants <40 days | gutsandgrowth

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