Another study (AS Danewa et al J Pediatr 2016; 169: 105-9) has shown that ondansetron (zofran) is effective for gastroenteritis. In children (n=170) between 3 months and 5 years with acute diarrhea and vomiting in India, a single dose of ondansetron (0.2 mg/kg) syrup prior to the use of oral rehydration therapy (ORT) improved outcomes.
Failure of ORT was 31% in those treated with ondansetron compared with 62% given placebo (P<.001). there was fewer vomiting episodes and lower rates of IVF usage in those who received ondansetron.
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