Hepatic Tumor Pointers

A grand rounds report (CK McLean et al. J Pediatr 2018; 193: 245-48) focuses on the presentation of a rare tumor in a neonate, angiosarcoma.  A few pointers from the discussion:

  • The most common benign hepatic vascular tumors are congenital hemangiomas and infantile intrahepatic hemangiomas (IHH)
  • The AAP dermatology section recommends assessing for hepatic lesions when there are 5 or more cutaneous hemangiomas.  The risk of a hepatic hemangioma may be 23%, according to one study, when there are >5 cutaneous hemangiomas or one large cutaneous hemangiomas.
  • “Consumptive hypothyroidism is a unique characteristic in some IHH.” This is due to tumor expression of a type 3 iodothyronine deiodinase enzyme which inactivates thyroid hormone.

Related blog post:

Bright Angel Trail, Grand Canyon

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