Mortality Rate with Autoimmune Hepatitis –Increased if Cirrhosis

Briefly noted: Using a Dutch database to identify 449 patients with autoimmune hepatitis, a recent study (FF van den Brand et al. Clin Gastroenterol Hepatol 2019; 17: 940-7) found that having associated cirrhosis increased the mortality rate over a 10-year followup.  In this circumstance, the standardized mortality ratio (SMR) was 1.9.  In contrast, if cirrhosis was not present, there was no significant increase in SMR (1.2).  Patients with overlapping PSC had the greatest increase in mortality with an SMR of 4.7.

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