Polyurethane vs Silcione with Ethanol Locks

Prior recommendations for ethanol locks have favored silicone central lines over polyurethane due to concerns of increased breakage rates when ethanol locks are used with polyurethane catheters. However, a recent small study indicates that this may be incorrect.

K LaRusso et al. JPEN https://doi.org/10.1002/jpen.2056. Prolonged Use of Ethanol Lock Prophylaxis With Polyurethane Catheters in Children With Intestinal Failure: A Single‐Center Experience (Reference from Conrad Cole’s twitter feed)

A 10‐year retrospective study with 10 children comprising 85 CVCs and 13,227 catheter days

Key findings:

  • Breakages were the most common complication: polyurethane 1.46/1000 vs silicone 3.76/1000 catheter days. Silicone catheters had a significantly higher breakage rate (adjusted rate ratio [RR], 2.86; 95% confidence interval [CI], 2.84–2.88; P < .001)
  • Polyurethane catheters had higher rates of occlusion (adjusted RR, 0.14; 95% CI, 0.07–0.28; P < .001) and displacements.
  • There were no differences in the overall catheter replacement rates and any other catheter‐related outcomes.

Related blog post: Central Line Pointers

From The Onion:

from The Onion