The following medications, paired with healthy eating and regular physical activity, are first-line medical options and result in moderate weight loss as noted as a percentage of body weight (reported as the difference compared to percent weight loss observed in the placebo group).
- Semaglutide (Wegovy®), weight loss percentage: 10.8%
- Phentermine-topiramate ER (Qsymia®), weight loss percentage: 8.5%
- Liraglutide (Saxenda®), weight loss percentage: 4.8%
- Naltrexone-Bupropion ER (Contrave®), weight loss percentage: 3.0%
Read the AGA Clinical Guidelines on Pharmacological Interventions for Adults with Obesity for the complete recommendations.