What is calretinin?

Calretinin is a ‘calcium-binding protein that is normally expressed in cholinergic nerves.’ (NEJM 2012:366: 361-72)  The absence of calretinin-positive mucosal neurites helps establish a diagnosis of Hirschsprung’s disease, even when suction-biopsy specimens may have previously been considered inadequate.  It is not known why calretinin neurites are absent in Hirschsprung’s disease nor why abnormal acetylcholinesterase-positive neurites are present.

More information on the technical aspects of diagnosing Hirschsprung’s disease and illustrations of these stains is available in this case record.

Additional references:

  • -Mod Pathol 2009; 22: 1379-84. Calretinin in Hirschsprung’s.
  • -Pediatr Dev Pathol 2009; 12: 6-15. Calretinin & acetylcholinesterase in Hirschsprung’s.
  • -JPGN 2011; 53: 75.  Problems post-op.
  • -JPGN 2008; 46:13.  Nice review.
  • -Pediatrics 2002; 109: 914-918.  Review of surgical treatments.
  • http://www.ccdhc.org/diseases/Hirschsprung.html

4 thoughts on “What is calretinin?

  1. Pingback: Primary Enteric Nervous System Disorders | gutsandgrowth

  2. Pingback: Reducing Diagnostic Uncertainty in Hirschsprung’s Disease | gutsandgrowth

  3. Pingback: Rectal Suction Biopsies Less Accurate in Infants <40 days | gutsandgrowth

  4. Pingback: Image Only: Total Colonic Aganglionosis | gutsandgrowth

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