This blog post title is quoted from a clever editorial which reviews the use of BMI and the effect of obesity with outcomes after liver transplantation (Liver Transpl 2014; 20: 253-54, related article pages 281-90.)
Key points from editorial and study:
- Study enrolled 202 consecutive adult (mean 51 years) patients (200-2010) as part of cohort study. Data was obtained at time of transplantation and reviewed with retrospective analysis. NAFLD was transplant indication in 7%.
- “Use of BMI as a marker of obesity is flawed.” Authors showed only 86% agreement between calculated BMI and percent body fat as measured with DXA.
- Patients with high BMI due to greater lean muscle mass may have improved outcomes. Sarcopenia (loss of muscle mass) likely has greater effect on outcomes.
- The study shows that the combination of diabetes and obesity increases the risk of complications and prolongs hospital stays (5.81 days, P<0.01).
- Metabolic risk factors had no effect on 30-day, 1-year, or 5-year patient survival.
Another article in same issue: Liver Transpl 2014; 20: 311-22. This study retrospectively examined 148 normal-weight, 148 overweight, and 74 obese patients who underwent living donor liver transplantation. Key finding: “there were no differences in graft survival [hazard ratio (HR) =0.955] or recipient survival [HR = 0.90]” between these groups. Obese patients do require larger grafts which can delay identifying suitable donor.
Bottomline from editorial: “this study shows us that the combination of diabetes and obesity dramatically increases the risk of complications” but not survival. “If there comes a day when the cost of a human life is less than the cost of a 6- to 7-day hospital stay, that is the day to reckon. None of us may survive.”
Related blog post:
Sarcopenia, fatigue, and nutrition in chronic liver … – gutsandgrowth