IBD Shorts -Skin, Adalimumab Kinetics

From the IMAgINE study with 192 pediatric patients (Sharma S et al. Inflamm Bowel Dis 2015; 21: 783-92), the authors determined levels for adalimumab, that at week 52, were associated with remission and response.  A cutoff level of 3.6 mcg/mL had a sensitivity of 32.7%  and specificity of 88.6% for predicting remission; the same cutoff had a sensitivity of 46.2% and specificity of 83% for predicting a response.  Overall, the authors noted dose proportionality with patients who received higher (or more frequent) doses with higher serum levels.

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“Concomitant Use of Azathioprine/6-Mercaptopurine Decreases the Risk of Anti-TNF-Induced Skin Lesions” (Soh JS et al. Inflamm Bowel Dis 2015; 21: 832-9). Among a cohort of 500 Korean patients, the incidence of psoriaform and eczematiform lesions was 6.2%.  Concomitant use of a thiopurine was associated with a hazard ratio of 0.452 (lower risk) for developing these adverse skin reactions.

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  1. Pingback: Characteristics of Skin Lesions Associated with Anti-Tumor Necrosis Factor Therapy | gutsandgrowth

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