I found a recent study (Paramsothy S. Inflamm Bowel Dis 2015; 21: 1600-06) interesting in that it shows how few individuals would qualify as long-term stool donors for fecal microbiata transplantation (FMT). In previous discussions with colleagues, I’ve thought that getting paid to donate stool would be a pretty sweet deal.
In this study, the authors examined 116 potential donors. The donor screening protocols and donor inclusion/exclusion criteria were similar to many others (outlined in their Tables 1, 2 and 3 & noted in previous gutsandgrowth blog post on FMT). What the researchers found is that 47 prospective donors declined to participate after learning the requirements and only 12 of the remaining 69 (17%) remained eligible after concluding screening; this represents only 10% of the initial cohort. A large proportion of healthy asymptomatic donors failed stool testing –40% of those tested. The next most common reasons for rejection were medication comorbidities (n=13) or risk factors for Creutzfeldt-Jakob disease (n=6).
Bottomline: Now, I realize how these stool donors should be justifiably proud of their carefully-balanced uncontaminated microbiome. The difficulty in identifying suitable donors further reinforces the value of human stool banks.
Vandenplas Y, et al. “Fecal Microbiota Transplantation: Just a Fancy Trend? JPGN 2015; 61: 4-7. Brief overview which includes screening protocol used in Brussels. One of the recommendations is to conserve a sample of the donated stool for >30 years.
Related blog posts:
- OpenBiome -Nation’s 1st Human Stool Bank | gutsandgrowth
- Clostridium difficile/Fecal Microbiota Transplantation Video …
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