CA Calarge et al. J Pediatr 2018; 201: 245-51. This study analyzed data from 4 separate trials with a total of 267 boys treated with risperidone. In this cohort, 71% had taken an SSRI.
Key finding: The duration and cumulative dose of SSRI was inversely associated with height z score, especially during Tanner 3 and 4 stages. The effect was approximately 1 cm for every year of treatment.
The authors speculate that SSRIs could “alter serotonin signaling, which is known to control GH secretion.”
- This study shows an association between SSRIs and linear growth but it remains unclear if this affects adult height (could postpone growth).
- This potential adverse effect needs to be considered in the clinical picture of the severe impairment and distress that can occur due to untreated depression and anxiety.