M Mouzaki et al. J Pediatr 2018; 201: 86-92. This study with 65 patients evaluated nonalcoholic fatty liver disease (NAFLD) progression between two MRI studies, with a median time span of 27 months.
Key findings:
- There was no correlation between change in liver stiffness and change in ALT; there was a weak correlation between ALT change and fat fraction.
- MRI fat fraction and stiffness decreased in 29% and 20% of patients respectively and increase in 25% and 22% respectively.
My take: When we find effective therapies, we will need better non-invasive markers to follow NAFLD progression.
Related blog posts
- NAFLD Guidance from AASLD 2018
- Pediatric NAFLD Guidelines 2017
- Concise Review: Fatty Liver in Pediatrics
- Ultrasound Unreliable to Exclude Fatty Liver
- A liver disease tsunami | gutsandgrowth
- Increasing prevalence of pediatric NAFLD | gutsandgrowth
Tea House Trail, near Lake Louise, Banff
gutsandgrowth 