I Kotikula et al. AP&T 2021; 54: 1026-1032. https://doi.org/10.1111/apt.16588. Randomised clinical trial: the effects of pregabalin vs placebo on functional dyspepsia
Key findings (8 week, randomized placebo-controlled study)
- The self-reported adequate relief rates in the pregabalin and placebo groups were 70.6% and 42.1% at week 4 (P = 0.02), and 70.6% and 44.7% at week 8 (P = 0.03), respectively
- Pregabalin improved the overall quality of life (P = 0.03)
- The most common adverse event with pregabalin was dizziness, occurring in 51.6% of patients
My take: In this study, pregabalin led to significant alleviation of dyspeptic symptoms, especially in patients with predominant epigastric pain.
Related blog posts:
- Are Gasroparesis and Functional Dyspepsia Part of The Same Problem?
- Brave New World: Psychotropic Manipulation & Pediatric …
- Cyproheptadine for dyspepsia | gutsandgrowth
- Will I Have This Stomach Pain Forever? (Part 1) | gutsandgrowth
- Will I Have This Stomach Pain Forever? (Part 2) | gutsandgrowth
- NEJM: Functional Dyspepsia
- Dreaded Nausea (2017) | gutsandgrowth
- A 6-Year Study of Amitriptyline, Escitalopram, and Functional Dyspepsia
Disclaimer: This blog, gutsandgrowth, assumes no responsibility for any use or operation of any method, product, instruction, concept or idea contained in the material herein or for any injury or damage to persons or property (whether products liability, negligence or otherwise) resulting from such use or operation. These blog posts are for educational purposes only. Specific dosing of medications (along with potential adverse effects) should be confirmed by prescribing physician. Because of rapid advances in the medical sciences, the gutsandgrowth blog cautions that independent verification should be made of diagnosis and drug dosages. The reader is solely responsible for the conduct of any suggested test or procedure. This content is not a substitute for medical advice, diagnosis or treatment provided by a qualified healthcare provider. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a condition.
Pingback: “How to Approach a Patient with Difficult-to-Treat IBS” | gutsandgrowth
Pingback: Epidemiology of Gastroparesis in Adults | gutsandgrowth