In 2009, a large prospective database involving Italian Pediatric Gastroenterologists was established. A recent study describes the classification (Paris) and phenotype of early-onset pediatric inflammatory bowel disease (EO-IBD) (Inflamm Bowel Dis 2014; 20: 597-605).
In 506 consecutive patients, 224 had Crohn’s disease (CD), 245 ulcerative colitis (UC) and 37 IBD-unclassified.
- 11% were aged 0-5 years, 39% 6-11 years, 50% were 12-18 years.
- UC was more frequently diagnosed in 0-11 years of age whereas as CD was more common in 12-18 years.
- EO-Crohn’s showed more frequent isolated colonic disease
- EO-UC noted 62% with pancolitis compared with 38% in 6-11 years and 31% in 12-18 year group
Take-home message: The authors conclude that “EO-IBD exhibits an extensive phenotype and benefit from aggressive treatment strategies, although surgical risk is similar to later-onset disease. A family history for IBD is not common in EO disease.”