“I don’t care how you get here
Just get here if you can”
–Oleta Adams, “Get Here”
A recent study (Kugathasan et al. JPGN 2016; 62: 252-8) reminded me of the aforementioned song lyrics. (Full lyrics: Get Here)
This randomized pilot study comparing two regimens for low Vitamin D levels (serum 25-OH Vit D <30 ng/mL). During a treatment period of 6 weeks, patients were randomized to treatment with Vitamin D3 (cholecalciferol) at 10,000 units or to 5,000 units per 10 kg per week. The maximum weekly dose in the first group was 50,000 units (IU) and the maximum dose in the latter group was 25,000 IU.
Both treatments were associated with improvement; in the higher dose group the mean serum level reached 49.2 whereas it was 41.5 in the lower dose group. Of note, this repletion effect was nearly lost by the 12-week followup.
- This study used Vitamin D3 (cholecalciferol) which has greater bioavailability than Vitamin D2 (ergocalciferol).
- No serious adverse effects were noted. The study monitored Calcium, and parathyroid hormone concentrations.
- The authors did not report any correlation with CRP values. This is important because other studies (Why Adding Vitamin D May Not Help IBD | gutsandgrowth)
have shown improvement in Vitamin D levels without vitamin D supplementation when underlying inflammation has been treated.
My take: This study shows that supplementation with Vitamin D is associated with improved levels –one can ‘get here’ with either regimen the authors studied. In those with low levels (not due to inflammation), it is likely that maintenance Vitamin D supplementation will be needed.
Related blog posts:
- Single High-Dose Oral Vitamin D Therapy (Stoss) for Children …
- Explaining the Vitamin D Paradox | gutsandgrowth
- Vitamin D, IBD, and Causality | gutsandgrowth
- Common to be “D-ficient” | gutsandgrowth
- Vitamin D deficiency and metabolism in pediatric… | gutsandgrowth
Disclaimer: These blog posts are for educational purposes only. Specific dosing of medications/diets (along with potential adverse effects) should be confirmed by prescribing physician/nutritionist. This content is not a substitute for medical advice, diagnosis or treatment provided by a qualified healthcare provider. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a condition.