Keep the Stool Cool for More Reliable Calprotectin

A recent study (S-M Haisma et al. Arch Dis Child shows that stool calprotectin levels stored at room temperature dropped nearly 20% after one day and dropped further over several days compared to baseline values, whereas calprotectin values remained reliable over six days for stool specimens stored at 4 degrees Celsius.

The authors conclude: “Calprotectin is not stable at room temperature. Children with IBD and their caretakers may be falsely reassured by low calprotectin values. The best advisable standard for preanalytical calprotectin handling is refrigeration of the stool sample until delivery at the hospital laboratory.”

Full text (link from KT Park’s twitter feed): Calprotectin instability may lead to undertreatment in children with IBD

Related blog posts:


8 thoughts on “Keep the Stool Cool for More Reliable Calprotectin

  1. Pingback: How Often is Arthritis a Presenting Feature of Pediatric IBD & How to Make the Right Diagnosis | gutsandgrowth

  2. Pingback: An Insurance Company Doing the Right Thing (with Calprotectin) | gutsandgrowth

  3. Pingback: What is the Calprotectin Threshold for Disease Progression in Crohn’s Disease? | gutsandgrowth

  4. Pingback: Narrowing the Workup for Chronic Abdominal Pain –Carlo DiLorenzo Was Right! | gutsandgrowth

  5. Pingback: New and Improved Biomarker Blood Test for Crohn’s Disease? | gutsandgrowth

  6. Pingback: IBD Update (November 2020) | gutsandgrowth

  7. Pingback: Normative Data for Fecal Calprotectin, age 4-16 yrs | gutsandgrowth

  8. Pingback: Calprotectin Less Accurate for Isolated Ileal Crohn’s Disease | gutsandgrowth

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.