A recent retrospective study (R Levy et al. J Pediatr 2019; 209: 233-5) analyzed the musculoskeletal presenting manifestations of pediatric inflammatory bowel disease (IBD).
In their cohort of 715 patients with IBD, 137 had arthritis and/or arthralgia. 28 of these 137 patients (3.9% of total cohort) had arthritis preceding the diagnosis of IBD and were eligible for this study. Only 23 had complete data and were compared with 46 children with arthritis due to JIA (n=21), FMF (n=7), and postinfectious arthritis (n=18).
- Patients with subsequent IBD diagnosis were more likely to have sacroiliac involvement (34.8% vs. 2.2%), more likely to have anemia (mean hgb 10.5 vs 12), more likely to have low albumin (mean 3.5 vs 4.3) and to have higher inflammatory markers (ESR 81 vs 46; CRP 6.6 vs 4.5 mg/dL)
- In patients with calprotectin levels, 5 of 6 were >300 mg/kg and one was borderline
- On direct questioning at time of IBD diagnosis, prolonged gastrointestinal symptoms (e.g. abdominal pain, diarrhea, weight loss, aphthous ulcers) were evident in 78%.
- 4 of the 23 (17.3%) were diagnosed with IBD during the primary investigation. Ultimately, Crohn’s diagnosis was established in 87% of the IBD group.
My take: This study is important for pediatricians and rheumatologists. ~4% of children presenting with arthritis have IBD. Careful interrogation for GI symptoms (and perianal exam) will avoid diagnostic delay in most patients as would a stool calprotectin. Features like sacroileitis, and abnormal labs should also increase the suspicion for IBD.
Briefly noted: In a study discussing pediatrician beliefs about JIA (MR Pavo, J de Inocencio, J Pediatr 2019; 209: 236-9) there is an important caveat for GI doctors:
“It is clear that booster vaccinations against measles, mumps, rubella, or varicella zoster virus, can be considered in patients receiving < 15 mg/m-squared/week of MTX [methotrexate]” (Pediatr Rheumatol Online J 2018; 16: 46).
Related blog post:
- IBD Update Feb 2019 -last entry shows study indicating that patients with IBD and arthritis were more likely to require biologics.
- Keep the Stool Cool for Calprotectin Measurement
- Calprotectin in Triaging Potential Pediatric IBD Cases
- Biomarkers identify patients who benefit and how
- Fecal Calprotectin Monitoring for IBD Relapse
- Best Fecal Marker for Crohn’s Disease: Calprotectin | gutsandgrowth
- Value of Calprotectin | gutsandgrowth
- Prospective Monitoring of Calprotectin for Crohn’s Disease …