A recent study (J Ahmad et al. Clin Gastroenterol Hepatol 2019; 17: 789-90) reviewed subjects in enrolled in drug-induced liver injury (DILI) prospective cohort to determine the frequency of sclerosing cholangitis (SC)-like changes in this population.  SC-like changes have previously been noted in up to 10% of DILI cases (Dig Liv dis 2015; 47: 502-7). In this study, 233 of 1487 subjects had underwent an MRI.

Key findings:

• Four of 56 (7%) with adequate quality images had SC-like images (4 with intrahepatic stricture and 1 with a common hepatic duct stricture as well)
• Patients with SC-like changes had a more severe initial injury noted and were more likely to develop chronic injury as noted by persistent lab abnormalities at 6 months

My take: This study indicates that a severe DILI can result in secondary sclerosing cholangitis.

Related blog posts:

• Advice on drug-induced liver disease
• Liver toxicity -where to look online | gutsandgrowth
• More data on DILI | gutsandgrowth
• Data on Drug-Induced Liver Injury | gutsandgrowth
• Predicting a Bad End in Drug-Induced Liver Injury | gutsandgrowth
• Big Study of PSC in Children
• PSC -Natural History Study (pediatric)
• Primary Sclerosing Cholangitis (PSC) –Natural History Study
•  Web is Better: Liver Toxicity from Herbs | gutsandgrowthh