A Ricciuto et al. Journal of Crohn’s and Colitis; 2020. jjaa197, https://doi.org/10.1093/ecco-jcc/jjaa197 Link: Diagnostic Delay Is Associated with Complicated Disease and Growth Impairment in Paediatric Crohn’s Disease
Methods: “We conducted a national, prospective multi-centre IBD inception cohort study, including 1399 children. Diagnostic delay was defined as time from symptom onset to diagnosis >75 th percentile.”
- In CD, diagnostic delay was associated with a 2.5-times higher rate of strictures/internal fistulae (HR 2.53, 95% CI 1.41-4.56)
- Every additional month of diagnostic delay was associated with a decrease in height-for-age z-score of 0.13 standard deviations
- Diagnostic delay was more common in CD, particularly small bowel CD
My take: Delays in diagnosis in this study were associated with stricturing/internal fistulising complications and growth impairment in paediatric CD. It is likely that inadequate treatment would increase the risk of these problems as well.
Related blog posts:
- “Positioning Biologic Therapies in the Management of Pediatric Inflammatory Bowel Disease” & 14% of U.S. Infected with COVID-19
- Do Biologics Alter the Natural History of Crohn’s Disease in Children?
- CCFA: Updates in IBD (2017) -Dr. Kugathasan lecture discussed the RISK study and reported that there is likely a window of opportunity to more favorably affect natural history of the disease
- Paris Classification of Pediatric Crohn’s Disease
- Delays in diagnosing Crohn’s disease (post from 2012)