In their introduction (KP Quinn et al. Clin Gastroenterol Hepatol 2016; 14: 1296-1301), the authors state the following: “Despite the widely held notion that pouchitis is a rare complication in FAP following IPAA, clinical experience at our institution suggests [it]…is underestimated.”
Methods: retrospective cohort study of all FAP patients who underwent IPAA (ileal ouch-anal anastomosis) from 1992-2015 at their institution (Mayo clinic), n=113.
- 25 (22.1%) developed pouchitis with a mean time to pouchitis of 4.1 years.
- Of the 25 who developed pouchitis, 72% had an acute course and 28% had a chronic course.
My take: While pouchitis does occur more commonly in IBD following IPAA, it does occur with FAP more frequently than previously described.
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