Briefly noted:
D Piovani et al. Gastroenterol 2019; 157: 647-59. This study examined environmental risk factors for inflammatory bowel disease after extensive literature review and assessment of meta-analysis.
9 factors that were associated with increased risk of IBD:
- smoking (CD)
- urban living (CD & IBD)
- appendectomy (CD)
- tonsillectomy (CD)
- antibiotic exposure (IBD)
- oral contraceptive use (IBD)
- consumption of soft drinks (UC)
- vitamin D deficiency (IBD)
- Heliobacter species (non-Helicobacter pylori-like) (IBD)
7 factors that associated with reduced risk of IBD:
- physical activity (CD)
- breatfeeding (IBD)
- bed sharing (CD)
- tea consumption (UC)
- high folate levels (IBD)
- high vitamin D levels (CD)
- H pylori infection (CD, UC, and IBD)
EL Barnes et al. Inflamm Bowel Dis 2019; 1474-80. In this review which identified 12 studies and 4843 with an IPAA ( ileal pouch-anal anastomosis) for ulcerative colitis, 10.3% were ultimately diagnosed with Crohn’s disease. Link to full text and video explanation: The Incidence and Definition of Crohn’s Disease of the Pouch: A Systematic Review and Meta-analysis
EV Loftus et al. Inflamm Bowel Dis 2019; 1522-31. In this study with 2057 adalimumab-naive patients, “the proportion of patients in HBI remission increased from 29% (573 of 1969; baseline) to 68% (900 of 1331; year 1) and 75% (625 of 831; year 6). Patients stratified by baseline immunomodulator use had similar HBI remission rates.” Full text: Adalimumab Effectiveness Up to Six Years in Adalimumab-naïve Patients with Crohn’s Disease: Results of the PYRAMID Registry
The following study was summarized in previous blog: Oral Antibiotics For Refractory Inflammatory Bowel Disease Full text link: Efficacy of Combination Antibiotic Therapy for Refractory Pediatric Inflammatory Bowel Disease