gutsandgrowth
Home | About Jay Hochman -Pediatric Gastroenterology Blog | Archives
ESPGHAN Guidelines for Diagnosing Coeliac Disease 2020
January 12, 2020 8:54 am
Briefly noted: S Husby et al. JPGN 2020; 70: 141-56.
Link to document: ESPGHAN Guidelines for Diagnosing Coeliac Disease 2020
Key recommendations for diagnosing celiac disease (CD):
- If CD is suspected, measurement of total serum IgA and IgA-antibodies against transglutaminase 2 (TGA-IgA) is superior to other combinations
- We recommend against deamidated gliadin peptide antibodies (DGP-IgG/IgA) for initial testing
- Only if total IgA is low/undetectable, an IgG-based test is indicated
- If TGA-IgA is ≥10 times the upper limit of normal (10× ULN) and the family agrees, the no-biopsy diagnosis may be applied, provided endomysial antibodies (EMA-IgA) will test positive in a second blood sample. HLA DQ2-/DQ8 determination and symptoms are not obligatory criteria
- In children with positive TGA-IgA <10× ULN at least 4 biopsies from the distal duodenum and at least 1 from the bulb should be taken
Related blog posts:
P’tit Train du Nord Linear Park
Posted by gutsandgrowth
Categories: Pediatric Gastroenterology Intestinal Disorder
Tags: celiac disease, diagnosis
« Older Newer »
Mobile Site | Full Site
Get a free blog at WordPress.com Theme: WordPress Mobile Edition by Alex King.
[…] ESPGHAN Guidelines for Diagnosing Celiac Disease in 2020 […]
By Best Screening For Celiac At All Ages | gutsandgrowth on October 9, 2020 at 7:04 am
[…] ESPGHAN Guidelines for the Diagnosis of Coeliac Disease 2020 […]
By Most Popular 2020 Posts | gutsandgrowth on December 31, 2020 at 7:03 am
[…] ESPGHAN Guidelines for Diagnosing Coeliac Disease 2020 | gutsandgrowth […]
By Very Low Risk of Malignancy with Celiac Disease and Even Lower After Starting a Gluten Free Diet | gutsandgrowth on January 18, 2021 at 7:01 am
[…] ESPGHAN Guidelines for Diagnosing Coeliac (Celiac) Disease 2020 […]
By Most Popular Posts of 2021 | gutsandgrowth on December 30, 2021 at 7:00 am