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Pediatric Gastroenterology

PPIs Associated with Increased Risk of COVID-19 Infection

Posted on July 7, 2020 by gutsandgrowth

Here is link to original study: Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors

Almario CV, Chey WD, Spiegel BMR. Increased risk of COVID-19 among users of proton pump inhibitors. Am J Gastroenterol 2020 (pre-print posted online July 7, 2020)

From ACG: Information Sheet and FAQs About Proton Pump Inhibitors (PPIs) and Risk of COVID-19

This study shows an association but does not prove that PPIs increase risk of COVD-19. Patients taking PPIs may have other attributes that increase their risk compared to those who are not taking PPIs.

Here is some more information on twitter thread of this topic:

3. Let's start with biological plausibility. There's a reason we have stomach acid; it helps sterilize food by killing pathogens. We've known for years that acid can rapidly inactivate certain viruses. For example, this 2004 study shows pH<5 inactivates SARS-CoV-1. pic.twitter.com/GxDXx8WxqG

— Brennan Spiegel, MD, MSHS (@BrennanSpiegel) July 7, 2020

11. We found PPIs were associated with a *dose-response* risk of #COVID19, meaning higher the dose, higher the risk. Twice daily PPI=3.7x risk. Once daily or less=2.2x risk. The effect persisted for long vs. short-term use. In contrast, less powerful H2RAs revealed no risk.

— Brennan Spiegel, MD, MSHS (@BrennanSpiegel) July 7, 2020

1 thought on “PPIs Associated with Increased Risk of COVID-19 Infection”

Pingback: New Data: Acid Blockers NOT Associated with Risk of SARS-CoV-2, SARS-CoV-2 in the Pancreas, & Vaccine Passport | gutsandgrowth

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