New Strategy to Overcome Severe Reactions to Peanuts

A recent study (N Engl J Med 2018; 379:1991-2001) showed that

Link to abstract: AR101 Oral Immunotherapy for Peanut Allergy

Methods: Participants with an allergic response were randomly assigned, in a 3:1 ratio, to receive AR101 (a peanut-derived investigational biologic oral immunotherapy drug) or placebo in an escalating-dose program. 

Conclusions: In this phase 3 trial of oral immunotherapy in children and adolescents who were highly allergic to peanut, treatment with AR101 resulted in higher doses of peanut protein that could be ingested without dose-limiting symptoms and in lower symptom severity during peanut exposure at the exit food challenge than placebo.

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