The INSPPIRE Group (CE Gariepy et al. JPGN 2017; 64: 95-103) has published consensus recommendations for acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP).
While the authors acknowledge the need for high-level evidence/further research, they provide a large number of consensus recommendations. These recommendations are succinctly summarized in Table 1 and Table 2. From a reader’s perspective, my preference would have been to separate the recommendations for ARP and CP rather than to intermix them (though many of the recommendations are the same for both conditions).
ARP specific recommendations:
- “Initial evaluation should include AST,ALT, GGT, Total bilirubin (fractionate if elevated), fasting lipids, and total serum calcium.”
- Evaluate for fat-soluble vitamin deficiency, and pancreatic exocrine insufficiency at least annually
ARP and CP recommendations:
- Consider ammonia and urine organic acids if there is a concern for undiagnosed metabolic disease.
- Check for celiac disease.
- Check for O&P if immunosuppressed, travel to endemic areas of Ascaris, or if peripheral eosinophilia.
- Evaluation of genetic causes: should include sweat chloride test and PRSS1 gene testing. Consider SPINK1, CFTR, and CTRC evaluation.
- Evaluate with MRCP (not ultrasound) acutely if GGT >2 x ULN or if direct bilirubin is elevated.
- Non-acutely, MRCP recommended to evaluate pancreatic ductal abnormalities. “When available, secretin-enhanced MRCP …should be obtained.” sMRCP can provide dynamic images of the pancreatic duct allowing differentiation of fixed from nonfixed lesions; this technique has not been widely adopted by pediatric radiologists compared with adult radiologists.
CP specific recommendations:
- Evaluate for fat-soluble vitamin deficiency, pancreatic exocrine insufficiency, and pancreatic endocrine insufficiency at least annually
The authors did not recommend checking serum IgG4 in the absence of associated systemic disease or suggestive imaging for autoimmune pancreatitis.
Briefly noted: J-H Choi et al. Clin Gastroenterol Hepatol; 2017: 15: 86-92. This study indicated that vigorous hydration with lactated ringer’s (LR) reduces risk of pancreatitis after ERCP. A potential inference would be that LR would be an optimal fluid for pancreatitis more broadly. (Related: Why an ERCP Study Matters to Pediatric Care | gutsandgrowth)
Related blog posts:
- Risk of pancreatitis with celiac disease | gutsandgrowth
- INSPPIRE for pancreatitis | gutsandgrowth
- For the pediatric pancreatologists | gutsandgrowth
- Chronic Pancreatitis in Pediatrics -Descriptive Study | gutsandgrowth
- RECURRENT PANCREATITIS AND GENETIC UNDERPINNINGS | GUTSANDGROWTH
- DOES PANCREAS DIVISUM CAUSE PANCREATITIS? | GUTSANDGROWTH
- HOW HELPFUL ARE ANTIOXIDANTS FOR CHRONIC PANCREATITIS PAIN …