A long time ago in a galaxy far far away, I was taught that children with esophageal atresia would have reflux for life due to dysmotility following repair. Thus, these children presumably should remain on acid blockers indefinitely. It turns out that this was fiction (just like Star Wars).
R Tambucci et al J Pediatrics 2021; 228: 155-165. Full text: Evaluation of Gastroesophageal Reflux Disease 1 Year after Esophageal Atresia Repair: Paradigms Lost from a Single Snapshot?
In this retrospective study with 48 children, the authors had the following key points:
- Microscopic esophagitis was found in 33 (69%)
- Pathological esophageal acid exposure on MII-pH was detected in 12 (25%)
- The presence of long-gap esophageal atresia was associated with abnormal MII-pH.
The authors conclude that “histological esophagitis is highly prevalent at 1 year after esophageal atresia repair, but our results do not support a definitive causative role of acid-induced GERD. Instead, they support the hypothesis that chronic stasis in the dysmotile esophagus might lead to histological changes.”
My take: Along with endoscopy, pH probe testing can be helpful in selecting which children with esophageal atresia should continue with PPI therapy.
Related blog posts:
- Guidelines for esophageal atresia-TEF
- How Long Should Be PPIs Be Used in Patients with Esophageal Atresia?
- Esophageal Diseases Special ~15% of Healthy Individuals have microscopic esophagitis
- Esophagitis in Pediatric Esophageal Atresia
- Increased Risk of Eosinophilic Esophagitis with Esophageal Atresia
- Never quite right | gutsandgrowth,
- Endoscopic Surveillance after Esophageal Atresia: Low Yield in Pediatrics
- Declining Role of Fundoplication in Esophageal Atresia, Too