Online Webinar –Annual Aspen Conference  —July 14, 2000

Below I’ve included a few slides and some notes; my notes may have errors of omission or transcription.

Biliary Atresia -Prompt Diagnosis and Screening Ronald Sokol

Key Points:

• We have NOT improved age of diagnosis in biliary atresia in the past 30 years
• Uniform screening of fractionated bilirubin has been effective in Texas:  Diagnostic Yield of Newborn Screening for Biliary Atresia Using Direct or Conjugated Bilirubin Measurements S Harpavat et al. JAMA 2020; 323: 1141-50
• Pale stools are usually NOT due to biliary atresia but should prompt investigation (eg. fractionated bilirubin)
• MMP-7 may improve diagnostic approach; unclear if MMP-7 performs well in all populations (eg. prematurity)
• Outcome key factors: age at diagnosis (goal less than 30-45 days) and surgeon/center

Related blog posts:

• Newborn Bilirubin Measurements To Identify Biliary Atresia | gutsandgrowth
• One More Problem with HIDA Scans
• Biliary Atresia Biomarkers 2020
• More data, More Nuance with MMP-7
• Will We Still Need Liver Biopsies to Diagnose Biliary Atresia in a Few Years?
• Diagnosing biliary atresia earlier | gutsandgrowth
• Helpful Review on Biliary Atresia | gutsandgrowth
• Biliary Atresia More Common in Preterm Infants | gutsandgrowth
• High Survival Rates for Biliary Atresia Patients Needing Liver Transplantation
• What to Expect After Pediatric Liver Transplantation: Cognitive Function and Quality of Life
• 30 -Year Outcomes with Biliary Atresia
• Outcomes of Liver Transplantation in Small Infants
• “Big Improvements for Smallest Recipients” with Bad Liver Disease