Briefly noted: F Humbel et al. Clin Gastroenterol Hepatol 2020; 18: 2019-2029. Association of Alterations in Intestinal Microbiota With Impaired Psychological Function in Patients With Inflammatory Bowel Diseases in Remission
In a prospective study with 171 adults with IBD in remission, the authors combined
- measures of psychological comorbidities and quality of life (QoL)
- microbial analysis with 16S rRNA high-throughput sequencing
- Microbiomes of patients with higher perceived stress had significantly lower alpha diversity
- Anxiety and depressive symptoms were significantly associated with beta diversity
My take: This study adds another dimension to the idea of bidirectionality between psychological well-being and course of inflammatory bowel disease. The microbiome may directly influence both psychological well-being and IBD activity.
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- Working Together to Improve Outcomes for Children with Inflammatory Bowel Disease | gutsandgrowth
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- IBD Updates: Depression and Crohn’s Disease
- There is No Healthy Microbiome
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