H Yanai et al. The Lancet 2021; The Crohn’s disease exclusion diet for induction and maintenance of remission in adults with mild-to-moderate Crohn’s disease (CDED-AD): an open-label, pilot, randomised trial https://doi.org/10.1016/S2468-1253(21)00299-5

In this open-label trial of adults with mild-to-moderate biologic naive Crohn’s disease, key findings:

• At week 6, 13 (68%) of 19 patients in the CDED plus partial enteral nutrition group and 12 (57%) of 21 patients in the CDED group had achieved clinical remission (p=0·4618)
• Among the 25 patients in remission at week 6, 20 (80%) were in sustained remission at week 24 (12 patients in the CDED plus partial enteral nutrition group and eight in the CDED alone group)
• 14 (35%) of 40 patients were in endoscopic remission at week 24 (eight patients in the CDED plus partial enteral nutrition group and six in the CDED alone group)

My take: Dietary therapy may be effective option for motivated adult patients with Crohn’s disease.

Related blog posts:

• CDED + PN: An Alternative Diet to Exclusive Enteral Nutrition?
• Head-to-Head: Nutritional Therapy vs Biological Therapy for Pediatric Crohn’s Disease Anti-TNF therapy was as effective or more effective than EEN
• Dietary Therapy for Inflammatory Bowel Disease This is good lecture review on dietary therapy
• Trial by Diet for Pediatric Crohn’s Disease
• Can IBD Be Treated with Diet Alone?
• Good Food and Bad Food for Crohn’s Disease -No Agreement | gutsandgrowth
• Pushing the Boundaries on Dietary Therapy for Crohn’s Disease: CD-TREAT
• Position Paper: Nutrition in Pediatric IBD
• CDED Diet for IBD/IBD Updates
• Specific Carbohydrate Diet | gutsandgrowth