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N Davidson et al. JPGN 2022; 75: 70-75. 6- and 12-Month Outcomes after 90:10 Enteral Nutrition Induction Therapy in Pediatric Crohn’s Disease

In this retrospective study (2013-2018), the authors examined outcomes in 105 children treated with a 90:10 enteral feeds (90% formula).

Key findings:

• 44/105 (42%) patients completed 8–12 weeks
• After induction, 18 continued EN maintenance with a 80:20 then 70:30 protocol; however, only 10 remained on EN at 6 months and 4 remained on EN at 12 months

The associated editorial (pg: 1-2) make several points:

1. While EEN is effective and safe, this study and others have shown poor adherence
2. It is unclear how exclusive enteral nutrition needs to be in order to be effective. And, many patients instructed to receive 90% of their calories as formula are likely consuming higher amounts of table foods
3. We still are working out which foods need to be excluded

My take: This study shows that EEN is NOT a practical option for most patients beyond induction. Only 4 patients remained on EEN at 12 months.

Related blog posts:

• Mediterranean Diet vs Specific Carbohydrate Diet for Crohn’s Disease
• CDED + PEN: An Alternative Diet to Exclusive Enteral Nutrition?
• Dietary Therapy for Inflammatory Bowel Disease This is a good lecture review on dietary therapy
• Trial by Diet for Pediatric Crohn’s Disease
• Can IBD Be Treated with Diet Alone?
• Good Food and Bad Food for Crohn’s Disease -No Agreement | gutsandgrowth
• Pushing the Boundaries on Dietary Therapy for Crohn’s Disease: CD-TREAT
• Position Paper: Nutrition in Pediatric IBD
• CDED Diet for IBD/IBD Updates
• Specific Carbohydrate Diet | gutsandgrowth