Practical information and advice on continuing or stopping drugs with associated hepatoxicity is available from a recent commentary (Gastroenterol Hepatol 2012; 8: 333-36).
Most drugs with a “bump” in aminotransferases do not need to be stopped. Many drugs induce an “adaptive response” in which elevated LFTs will spontaneously resolve; this is most common in the first 12 weeks of drug usage. This type of response must be distinguished from an immune reaction/hypersensitivity response which is much more likely to progress. A hypersensitivity response could include rash, fever, and eosinophilia.
Recommended STOP RULES:
- Drugs that cause symptomatic hepatitis: abdominal pain, jaundice, loss of appetite.
- ALT values that exceed 8 times the ULN
- ALT values >3 times the ULN and Bilirubin >2 times the ULN
- If the ALT value is >3 times the ULN but not associated with symptoms or rise in bilirubin, the drug can likely be continued with periodic monitoring.
- ALT values >5 times the ULN require more intensive monitoring.
- Hy’s law (named for Hyman Zimmerman): AST or ALT > 3 ULN AND bili > 3 ULN indicate serious hepatotoxicity with >10% mortality rate.
- Statins have similar rates of hepatotoxicity as the general population
- Acetaminophen accounts for 40-50% of the 2000-2500 U.S. cases per year of acute liver failure (ALF). Of the remaining cases of ALF, about 12% (250-300) are due to other cases of DILI. Isoniazid is the 2nd most common cause of ALF due to DILI with about 50 cases.
- Potential risk factors for DILI include alcohol usage, obesity, adult age group, and female gender.
Additional blog entries and references:
When death is on the line
Pediatric pharmaceutical poisoning
- -J Pediatr 2011; 158: 802. Developing liver toxicity with valproic acid (VPA) is a contraindication to OLTx (even in the absence of documented mitochondrial dz). Rx with carnitine and d/c VPA. 82% of 17 children died w/in 1 yr of OLTx. POLG1 mutations are associated with Alpers syndrome. (Ann Neurol 2004; 55: 706.)
- -NEJM 2009; 360: 1575. propylthiouracil assoc c liver failure in ~1 in 2000
- -JPGN 2008; 47: 395-405. Drug-related hepatotoxicity and acute liver failure.
- -NEJM 2003; 349: 474. (review)
- PDF] What Do We Mean by Looking? FDA powerpoint with related information
The title is misleading; the most frequent treatments are unproven and not tailored well to the numerous disorders lumped under the term ‘mitochondrial disease.’ A nice review on what’s up-to-date with ‘mito’ disorders is in a recent NEJM (NEJM 2012; 366; 1132-41).
The first part of the review details the structure and function of the mitochondria including those pesky pathways for the production of ATP: glucose –>pyruvate through glycolysis. In turn, pyruvate –>lactate –>acetyl coenzyme A (CoA). Acetyl CoA generates NADH & flavin via tricarboxylic acid cycle. Fatty acids and glutamine can also serve as substrates. NADH & FADH2 fuel oxidative phosphorylation through five coupled mitochondria protein complexes. Coenzyme Q10 helps transport electrons across the complexes.
Primary and secondary mitochodrial disorders.
- 1000 genes encoding mitochondrial proteins have been identified in humans
- 228 mutations of protein-encoding nuclear DNA (nDNA) and 13 mitoDNA (mtDNA) have been linked to human disorders
- Secondary mito disorders include mito dysfunction due to viral infections and ‘off-target’ drug effects. Specific drugs include valproic acid, statins, halothane, doxorubicin, and aspirin
- Mito dysfunction is seen in a number of other diseases including Alzheimer’s, Parkinson’s, cancers, cardiac disease, diabetes, and obesity
Diagnosis: Biopsy specimens from patients can be studied to assess cellular and mitochondrial physiology in comparison to healthy samples. This review does not discuss molecular testing for mutations; however, an extensive list of genes associated with mitochondrial disorders (mtDNA & nDNA) is listed in Figure 2; a supplementary online appendix to the article explains these mutations in more depth.
Four potential treatments –all with a goal of increasing ATP production:
- genetic therapy
- small molecule treatment
- metabolic manipulation
Previous Cochrane review (2006) has not found evidence to support the use of any therapeutic interventions. More recent trials have shown limited positive effects on clinical or biochemical end points but have not led to a New Drug Application with the FDA. A few specific disorders that have treatments include the following:
- Idebenone (a CoQ10 variant) for Friedreich’s ataxia & Leber’s hereditary optic neuropathy
- Ketogenic diet for improving seizures in children with electron-transport defects
- Cyclosporin A for secondary mito dysfunction in Ulrich’s congenital muscular dystrophy & Bethlem’s myopathy
- Overview of current trials: http://www.clinicaltrials.gov/ct2/results?term-mitochondrial+disease
As one of my colleagues (LS) has said, making a diagnosis of a mitochondrial disorder is like getting the license plate of the bus that ran you over. Until treatments improve, this is pretty much the case.
- -Mitochondrion 2011; 11: 679-85. Why are there no proven therapies for genetic mitochondrial diseases?
- -J Pediatr 2011; 158: 802. Developing liver toxicity with VPA is a contraindication to OLTx (even in the absence of documented mitochondrial dz). Rx with carnitine and d/c VPA. 82% of 17 children died w/in 1 yr of OLTx. POLG1 mutations are associated with Alpers syndrome.
- -Pediatrics 2007; 120: 1326. Diagnosis and complications of mitochondrial disease.
- -Pediatrics 2007; 119: 722. long-term outcome of mito dz –variable.
- -NEJM 2003; 348: 2656. Review