J Rutsky et al. JPGN 2024;79:622–630. Open Access! Predictors of celiac disease in patients with type 1 diabetes and positive tissue transglutaminase immunoglobulin A

This was a retrospective single-center study with 123 patients -60% had biopsy-proven celiac disease (CD).

Key findings:

• Higher titers were more likely to be associated with CD. The degree of TTG IgA elevation in patients with T1DM is correlated with the risk of CD; for every 10‐fold increase in TTG IgA, there is a 4.7× increased risk of celiac diagnosis.
• However, even with TTG IgA >10 x ULN, only 85% had CD.

My take: Currently, the non-biopsy approach for CD diagnosis should not be used in patients with type 1 diabetes mellitus.

Related blog posts:

• Celiac Disease: Pro Tips (Part 1)
• Why Celiac Serology Needs To Be Looked At Differently in Children with Type 1 Diabetes
• Celiac Diseaase and Diabetes
• Reappraisal of the Risk of Autoimmune Disease with Celiac, Plus One
• Celiac Disease: Pro Tips (Part 2)
• Celiac Disease: Pro Tips (Part 3)
• Celiac Disease: Pro Tips (Part 4)
• No-Biopsy Approach to Celiac Disease Diagnosis and Positive Predictive Value (Based on Population)
• ESPGHAN Guidelines for Diagnosing Coeliac Disease 2020

D Blumenthal et al; NEJM 2024; DOI: 10.1056/NEJMp241085. The Failing U.S. Health System

This article succinctly explains why the U.S. health system spends a lot and has the worst performance of similar countries.

Some excerpts:

• “In Mirror, Mirror 2024, the Commonwealth Fund’s eighth report since 2004 comparing the health systems of 10 high-income countries…The United States has the lowest life expectancy among the 10 countries we studied, 4 years less than the 10-country average.”
• “It also ranks last on measures of preventable mortality and “treatable mortality”…These measures capture deaths that could have been averted by means of preventive services or timely and effective treatment, such as deaths from hypertension, diabetes, cerebrovascular disease, ischemic heart disease, or renal failure. The United States had the highest excess mortality attributable to Covid-19 among people younger than 75 years of age in 2021. It also has the highest rate among the 10 countries of death from self-harm, which includes deaths by suicide, and the highest rate — by orders of magnitude — of death from assault, which includes deaths caused by gun violence.”
• “The United States ranks last on measures of access to care and equity of care…Another contributor to access barriers is inadequate coverage among insured Americans because of high deductibles and copayments.”
• ” The Affordable Care Act and related policies reduced the proportion of uninsured people to its current level of 7 to 8%. But 26 million Americans still lack insurance.”
• “Providing insurance, however, will not be sufficient. The U.S. health care delivery system has profound problems … One such problem is the country’s worsening shortage of primary care clinicians”
• ” the high prices charged by U.S. health care facilities and professionals, which far exceed prices in other health systems.³ … One of the reasons health care organizations are able to charge such high prices is that they have obtained increasing economic power in local markets as a result of consolidation — both horizontal consolidation among hospitals and vertical consolidation, which involves large organizations acquiring physician practices. The arrival of private equity investors who “roll up” physician practices in local markets and then raise prices has also contributed to the escalation of U.S. health care costs.⁴“
• “The United States lags behind comparator countries when it comes to addressing the social determinants of health, such as poverty, homelessness, inequality, and hunger.”

My take (borrowed from authors): “What is the future of a country that allows an untold number of its people to suffer and die unnecessarily because of a lack of access to basic health services, inadequate public health measures, and a tattered social safety net?”

Related blog posts:

• “More Than Half a Million Extra Deaths” Every Year In U.S.
• NY Times: America can afford a world-class health system. Why don’t we have one? | gutsandgrowth
• Life Expectancy Dropping in U.S.
• What Is Driving Hospitals’ Acqui$ition of Physician Practices?
• “Health Insurance Is Broken” | gutsandgrowth
• When Hospitals Look Like The Ritz (But Cost Even More)
• “America’s Huge Health Care Problem” | gutsandgrowth
• “Do Nonprofit Hospitals Deserve Their Tax Exemption?”
• Healthcare: “Where the Frauds Are Legal”
• Medical Billing Trap: Hospital Pricing for Urgent Care Visits and Outpatient Departments
• NPR: Drugmakers Claim to Lose Money in US In Order to Avoid Taxes
• Heroes, Villains and ‘Perverse’ Incentives. Story of Big Hospitals vs. Big Pharma | gutsandgrowth
• Worse Outcomes After Hospital Mergers | gutsandgrowth

• SR Lieber et al. Liver Transplantation 2024; 30: 932-944. The financial burden after liver transplantation is significant among commercially insured adults: A large US National Cohort
• NN Ufere et al. Liver Transplantation 2024;30:918–31. Financial burden following adult liver transplantation is common and associated with adverse recipient outcomes.
• G Cholankeril, S Fasiha. Liver Transplantation 2024; 30: 873-874 (editorial). Open Access! Unseen foe: The financial toxicity of liver transplantation
• D Ladner, C Manski. Liver Transplantation 2024; 30:875-876 (editorial) Financial burden of cirrhosis is significantly reduced after liver transplantation

Using a nationally representative database spanning the years 2006-2021 with 1412 recipients, Lieber et al describe the patient financial burden after LT. Key findings:

• 21% had extreme liability > $10K for 1-year post-LT care
• 69% paid between $1 and 10K, with 48% having liability >$5K in the initial year following LT
• Medication costs comprised ~30% of outpatient financial liability
• Potential indirect costs from wages lost were $2,201–$6,073 per person

Ufere et al surveyed 207 adult recipients of liver transplant across 5 US transplant centers. Key finding: Nearly 1 in 4 experienced high financial burden (>/= 10% annual income spent on out-of-pocket costs)

The editorial by Ladner et al. notes that “LT is the only curative treatment for cirrhosis, with a 5-year survival of over 80% and, in most cases, returning patients from a chronic disease state to full physical and mental health.⁶ However, LT is resource-intensive, associated with an average cost of >$700,000, and is only performed in ~10,000 patients every year due to many barriers, including limited organ supply.⁷ Hence, this lifesaving therapy is currently provided to less than 1% of the patients affected by cirrhosis.⁸“

Ladner et al note that the financial burden of cirrhosis, though, is reduced after LT. “Without LT, the best that a patient can anticipate is to continue living with chronic liver disease/cirrhosis, with a baseline out-of-pocket cost of $19,390 per year. In this context, receiving an LT appears to be cost-saving for most (>80%) recipients of LT rather than a financial burden—with only 21% of recipients of LT having out-of-pocket costs >$10,000 during the first year after LT. In fact, the average out-of-pocket costs following LT appear quite similar to the $5,567 costs reported by patients without liver disease.⁵“

My take: LT is expensive. The financial burden needs to addressed with patients. However, for patients with cirrhosis, LT is usually a good value with lower out-of-pocket costs for 80% of recipients along with better quality of life, and longevity.

Related blog posts:

• Costs and Opportunity Costs in Pediatric Liver Transplantation
• Unfortunate or Unfair Disparities in Liver Transplantation
• Liver Shorts: Relationship of Hepatic Steatosis to Cardiovascular Disease and the Cost of Liver Transplantation
• What Can Go Wrong with Living Liver Transplantation for the Donor
• How to Lower Pediatric Liver Transplantation Waitlist Mortality

W Afif et al. Am J Gastroenterol; 119: 910-921. Open Access! Efficacy and Safety of Ustekinumab for Ulcerative Colitis Through 4 Years: Final Results of the UNIFI Long-Term Maintenance Study

Background: In the initial UNIFI study, 44% and 38% remission rates were seen after 44 week treatment among patients with and without prior biologic exposure (See post: Ustekinumab for Ulcerative Colitis (UNIFI Trial)).

Methods: Ustekinumab induction responders who completed 44 weeks of maintenance treatment and agreed to enter the long-term extension continued their subcutaneous maintenance therapy (90 mg ustekinumab every 8 or 12 weeks [q8w or q12w] or placebo). Starting at week 56, randomized patients could receive dose adjustment to 90 mg q8w. 

Key findings:

• Of the 348 patients randomized to subcutaneous ustekinumab at maintenance baseline (q8w and q12w combined), 55.2% were in symptomatic remission at week 200.
• A greater proportion of biologic-naive patients (67.2% [117/174]) were in symptomatic remission than those with a history of biologic failure (41.6% [67/161]).
•  Of the 171 patients with endoscopic evaluation at week 200, 81.6% (71/87) in the q12w group and 79.8% (67/84) in the q8w group had endoscopic improvement.
• Safety: From weeks 156 to the final safety visit (up to week 220), no deaths, major adverse cardiovascular events, or tuberculosis occurred in patients receiving ustekinumab. Nasopharyngitis, UC worsening, and upper respiratory tract infections were the most frequently reported adverse events. “Exposure-adjusted analysis showed that ustekinumab AE rates were not greater than placebo.”
• Immunogenicity: Overall, 5.5% (22/400) of randomized and nonrandomized patients who continued ustekinumab in the LTE were positive for ADA through the final safety visit. Overall, 5 of these 22 patients (22.7%) were positive for neutralizing antibodies. ADA were often transient and seemed to have no effect on efficacy.

My take: About ~25% of patients starting ustekinumab can expect to be in remission after 4 years based on this study. This estimate is based on a remission rate of ~55% at 200 weeks after achieving clinical remission in ~44% of the initial cohort patients at 44 weeks of treatment. The study provides additional data regarding a favorable safety profile.

Related blog posts:

• Ustekinumab for Ulcerative Colitis (UNIFI Trial)
• Upadacitinib vs Ustekinumab for Ulcerative Colitis
• Comparative Efficacy of Biologics for Crohn’s Disease
• Is Risankizumab More Effective for Crohn’s Disease Than Ustekinumab?
• How Much Ustekinumab (Stelara) Is Needed to Get a Good Response
• Comparative Efficacy: Infliximab vs. Ustekinumab
• Risankizumab Outperforms Ustekinumab (for Crohn’s disease)

Disclaimer: This blog, gutsandgrowth, assumes no responsibility for any use or operation of any method, product, instruction, concept or idea contained in the material herein or for any injury or damage to persons or property (whether products liability, negligence or otherwise) resulting from such use or operation. These blog posts are for educational purposes only. Specific dosing of medications (along with potential adverse effects) should be confirmed by prescribing physician.  Because of rapid advances in the medical sciences, the gutsandgrowth blog cautions that independent verification should be made of diagnosis and drug dosages. The reader is solely responsible for the conduct of any suggested test or procedure.  This content is not a substitute for medical advice, diagnosis or treatment provided by a qualified healthcare provider. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a condition.

S Singh et al. Clin Gastroenterol Hepatol 2024; 22: 923-932. Open Access! Common Instances of Low-value Care in Inflammatory Bowel Diseases

• “Serological tests such as pANCA, ASCA, and other serological anti-microbial antibody tests for the diagnosis of IBD in patients with non-specific symptoms or in those with negative endoscopic and radiologic evaluation represents low-value care.“
• “Making major therapeutic decisions based only on the presence of symptoms in patients with IBD, particularly CD, without objective confirmation of inflammation, represents low-value care. “

• “Use of 5-ASA for the management of CD, particularly for patients at high risk of disease-related complications, represents low-value care. The safety of these medications must not be confused for their lack of efficacy in this setting. The utility of 5-ASA in a subset of patients with mild colonic CD who are at low risk of disease-related complications remains to be adequately studied.”
• “Routine continuation of oral 5-ASA in patients with IBD who have been escalated to advanced therapies represents low-value care. Selective use of 5-ASA, particularly topical therapy in patients with persistent symptoms of proctitis despite optimized biologics may be appropriate.”
• “Premature discontinuation of TNF antagonists in patients with IBD with partial but inadequate response or loss of response (after initial improvement) to index agent, without an attempt with accelerated dosing or therapeutic drug monitoring to potentially optimize therapy, represents low-value care.”
• “Failure to consider dose de-escalation of TNF antagonists in patients who have achieved stable and persistent remission with intensive dosing regimens may represent low-value care.“

“Prolonged use of high-dose intravenous corticosteroids beyond 5 to 7 days without significant clinical improvement, in patients hospitalized with ASUC, represents low-value care. In these patients, escalation to rescue medical therapy or surgery should be strongly considered.”

My take: If the comedian Jeff Foxworthy wrote this article, each of the opinions would have started off with ‘You might be wastin money if…’

PW Chang et al. Clin Gastroenterol Hepatol 2024; 22: 1917-1925. ChatGPT4 Outperforms Endoscopists for Determination of Postcolonoscopy Rescreening and Surveillance Recommendations

Text input of de-identified data into ChatGPT4 from 505 consecutive patients undergoing colonoscopy between January 1 and April 30, 2023. Key findings:

• ChatGPT4 recommendations were in closer agreement with the USMSTF Panel (85.7%) than gastroenterology practice recommendations with the USMSTF Panel (75.4%) (P < .001).
• Of the 14.3% discordant recommendations between ChatGPT4 and the USMSTF Panel, recommendations were for later screening in 26 (5.1%) and for earlier screening in 44 (8.7%) cases. 

My take: Incorporating AI in deciding follow-up surveillance is likely to be a helpful tool.

Related article: K-H Yu et al. NEJM 2024; 390: 1895-1904. Medical Artificial Intelligence and Human Values. This article discusses how human values affect the results of AI advice.

Related blog posts:

• ChatGPT for Colonoscopy Questions Plus One
• ChatGPT Passes the Bar, an MBA exam, and Earns Medical License?
• Have you tried out ChatGPT?
• Chatbots Helping Doctors with Empathy
• AI Skirmish in Prior Authorizations
• Medical Diagnostic Errors

M Xue et al. Clinical Gastroenterology and Hepatology, Volume 22, Issue 9, 1889 – 1897.e12. Open Access! Environmental Factors Associated With Risk of Crohn’s Disease Development in the Crohn’s and Colitis Canada – Genetic, Environmental, Microbial Project

Methods: The authors prospectively followed 4289 healthy first-degree relatives (FDRs) of patients with CD from the Crohn’s and Colitis Canada – Genetic, Environmental, Microbial (CCC-GEM) project. Regression models identified environmental factors associated with future CD onset and their association with pre-disease biological factors, including altered intestinal permeability measured by urinary fractional excretion of lactulose to mannitol ratio (LMR); gut inflammation via fecal calprotectin (FCP) levels; and fecal microbiome composition through 16S rRNA sequencing.

Key findings:

• Over a 5.62-year median follow-up, 86 FDRs developed CD
• Living with a dog between ages 5 and 15 (hazard ratio [HR], 0.62; P = .034) was associated with decreased CD risk
• Living with a dog was associated with reduced LMR, altered relative abundance of multiple bacterial genera, and increased Chao1 diversity.
• Living with a large family size in the first year of life (HR, 0.43; P = .016) was associated with decreased CD risk
• Having a bird at the time of recruitment (HR, 2.78; P = .005) was associated with an increased CD risk (though there were relatively few FDRs with birds at baseline, n=136)
• Limitations: questionnaire-based assessments of environmental exposure can be subject to recall bias

My take (borrowed from authors): “Our findings contribute to the growing evidence supporting the potential health benefits of exposure to pets, particularly dogs, as a potential preventive strategy for individuals at risk of developing CD.” Having a dog during childhood may reduce the later risk of CD by ~40%.

Related blog posts:

• Risk Factors for Inflammatory Bowel Disease: Ultra-Processed Food (Part 1)
• Ultraprocessed Food and the Risk of Inflammatory Bowel Disease
• Risk Factors for Inflammatory Bowel Disease: Antibiotics (Part 2)
• Early Antibiotics -Minimal Risk for Crohn’s Disease
• Passive Smoking and Worsening Crohn’s Disease
• Emigration -One Way to Acquire Inflammatory Bowel Disease | gutsandgrowth

S.A Abrams, R.J. Shulman. The American Journal of Clinical Nutrition, https://doi.org/10.1016/j.ajcnut.2024.08.028. Open Access! What would happen in the United States if there were no cow milk-based preterm infant nutritional products: Historical perspective and evaluation of nutrient-related challenges

Background: “Recent legal action (1) has raised the possibility that preterm cow milk-based infant nutritional products (PCMBPs) may either not be produced and available in the United States or may require parental consent and warnings making them extremely difficult for caregivers to use and families to accept (2).”

Key points:

• “Evidence that unfortified human milk is inadequate to meet the nutrient needs of small preterm infants has been present for over 100 years (6). Until the late 1970’s and early 1980’s, there were limited widely available solutions to either fortify or replace human milk for preterm infants and these were often based on providing feedings of concentrated evaporated cow milk; now recognized as woefully inadequate and unsafe (7 ). At that time, specialized formulas that were high in energy, protein, and micronutrients were widely introduced into the market. Early studies confirmed faster growth of infants fed such products compared to unfortified human milk or full-term formula (8) and their use became widespread by by the mid-1980s.”
• “The availability of PCMBPs as well as a human milk-based human milk fortifier has led to relatively less frequent and severe nutritional failure in very low birth weight, less than 1500 g (VLBW) infants than in earlier eras. Nonetheless growth failure remains a current problem, especially in the smallest of infants, that is, those less than 1000 g birth weight and less than 25 weeks post-menstrual age at birth (12).”
• “Inadequate growth and mineralization can be expected to lead to long-term developmental disability, bone demineralization, and frank rickets”
• “Even with such improvements in policy to support breastfeeding and human milk donations, it is unlikely that an all human milk-based diet could be available for many years if ever for most of the preterm infants born in the US each year, either in the NICU or after hospital discharge.”
• “Supplements for infants who are over a year of age.. are not suitable for preterm infants, especially those in the first 6 to 9 months after birth. They have relatively high osmolality and nutrient levels, would pose substantial risks of intolerance, and would not meet the specific nutrient requirements of this population.”
• “The process of individualizing or creating multi-component fortification strategies would be daunting and carries risks of contamination, preparation errors, and tolerance issues. Without proper fortification, preterm infants are at a high risk of growth failure and its associated negative impacts on development and even survival.”

My take: Experts in the field of neonatal nutrition are worried that recent litigation will negate decades of nutritional advances in neonatal care. This is a very real threat. In addition to more complications, the litigation will result in much greater expenses for all infants/families.

Related blog post: Proliferation of Formula Lawsuits In Necrotizing Enterocolitis