COVID Vaccine Myths and Facts from ACG

ACG: 1Fact/1Myth: Dispelling Misinformation on COVID-19 Vaccine

Some of the slides:

Full set of Slides: ACG_COVID_Vaccine Slide Set PDF

Related blog posts:

COVID-19 Vaccine in Israel & Effectiveness for Variants

From BBC (1/25/21): Moderna vaccine appears to work against variants

An excerpt:

“For the Moderna study, researchers looked at blood samples taken from eight people who had received the recommended two doses of the Moderna vaccine. The findings¬†are yet to be peer reviewed, but suggest immunity from the vaccine recognises the new variants. Neutralising antibodies, made by the body’s immune system, stop the virus from entering cells.

Blood samples exposed to the new variants appeared to have sufficient antibodies to achieve this neutralising effect, although it was not as strong for the South Africa variant as for the UK one. Moderna says this could mean that protection against the South Africa variant might disappear more quickly.”

More on COVID-19 Vaccines

Yesterday, Evan Anderson (infectious disease) shared some updates on COVID-19 vaccines.

  • Dr. Anderson noted that more research is needed in children, pregnant women and immunocompromised populations. Immunocompromised patients may have a lower response rate to vaccination.
  • The South African 501Y.V2 COVID-19 variant may be less responsive to neutralization from donor plasma and the vaccines may be less effective in this variant.
  • He reviewed ACIP recommendations -available from CDC website as well
  • Dr. Anderson noted there is a good response to vaccination even in those with a lack of adverse effects with vaccination
  • Immunity after vaccination: data has been published showing good antibody levels at 3 months. Moderna has stated that they expect vaccine will provide immunity for at least a year
  • Immunity after infection with COVID-19: at least 3 months. Those with milder infection are more likely to get reinfected.
  • Antibody testing after vaccination to assess for immunity is not recommended

Vaccination Recommendations for IBD Patients

From COVID-19 Memorial in Washington D.C. 1/19/21

Siegel CA, Melmed GY, McGovern DP, et al. Full text link: SARS-CoV-2 vaccination for patients with inflammatory bowel diseases: recommendations from an international consensus meeting Gut  Published Online First: 20 January 2021. doi: 10.1136/gutjnl-2020-324000

From David Rubin’s Twitter Feed

In the article, they note “the exception is for any live-attenuated virus vaccines or replication-competent viral vector vaccines that come to market.” Currently, all of the vaccines are inactivated (not live-attenuated).

These recommendations apply to approved populations which currently do not include pediatric patients or patients who are pregnant.

Related blog posts:

From Children’s Healthcare of Atlanta:

NPR Story: How Clinic Staff Decided to Accept COVID-19 Vaccine

NPR (Jan 12, 2021): How Health Care Workers Made Up Their Minds On The COVID-19 Vaccine At One Mass. Clinic

“A doctor researched the safety of the COVID-19 vaccinations not only to counsel his patients and staff but also to make his own decision about whether to get the vaccine.

Carey Goldberg of WBUR has the story about how most of the staff at the Cambridge Health Alliance COVID-19 clinic in Somerville, Massachusetts, “got to yes.”

22 minute presentation: COVID Vaccine Primer available at NPR website is a really good presentation (for more widespread adoption)