Increased Risk of Eosinophilic Esophagitis in Esophageal Atresia Patients

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Briefly noted: U Krishnan et al. Analysis of eosinophilic esophagitis in children with repaired congenital esophageal atresia. JACI 2018. Published online Oct 24, 2018.

This retrospective, single-center study examined 4 eosinophilic esophagitis (EoE) study cohorts and identified EoE in 20 of 110 patients (18%) who had surgically-repaired esophageal atresia.

This association has been seen previously: . 2014 Dec 21; 20(47): 18038–18043.  This case study stated ” We are suggesting that EoE is a frequent concomitant problem in patients with history of congenital esophageal deformities, and for this reason any of these patients with refractory reflux symptoms or dysphagia (with or without anastomotic stricture) may benefit from an endoscopic evaluation with biopsies to rule out EoE.”

Related blog posts:

Transpyloric Feedings -A Reassessment

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A recent commentary (MH Wallenstein, DK Stevenson. JAMA Pediatr. 2018;172(11):1004-1005.) discusses the potential advantages of transpyloric feedings in premature infants. Thanks to Ben Gold for this reference.

Key points:

  • First, preterm infants are highly susceptible to pulmonary aspiration, primarily due to, among other factors, immature tone of the lower esophageal sphincter and use of uncuffed endotracheal tubes.”
  • Second, aspiration of gastric contents probably contributes to bronchopulmonary dysplasia..
  • Third, transpyloric feeding is an effective strategy to reduce the risk of aspiration…we believe that early prophylactic transpyloric feeding may be the only effective strategy to prevent aspiration-associated lung injury.
  • Transpyloric feedings “fell out of favor in the 1980s after a single trial showed an increased risk of mortality”

My take (borrowed from authors): “the practice of early transpyloric feeding with human breastmilk merits a thorough reevaluation of its risks and benefits in the setting of modern neonatal practice.”

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Time to Change Upper GI Default Orders -No Routine Scout

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When I place an order for an upper GI, the computer prompt asks whether this should be with or without a scout film.  A recent retrospective study (S Abdullah et al. JPGN 2018; 67: 576-9) provides data indicating that the default setting should be without a scout xray.

After reviewing UGIs in 197 outpatients over a 2 year period, the authors found that

  • 97% found no significant findings in scout xray
  • 1.5% (n=3) had findings that were not addressed
  • 1% (n=2) had findings that required additional evaluation –both minor lung findings, later deemed insignificant
  • 0.5% (n=1) had a finding which resulted in a change in management –>a cleanout for excessive stool.  The report does not state whether this patient had a rectal exam which generally is more accurate with regards to the need for a cleanout

My take: This study provides convincing data that scout studies are usually unnecessary.  For inpatients, the main reason to order a scout xray would be if a patient had previous contrast that needs to be cleared prior to UGI.

Related blog post: Pre-PEG UGIs Often Unnecessary

Lake Maligne, near Jasper Canada

Why Pureed Food Pouches Are Not a Good Idea for Young Children

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A recent editorial (B Koletzko et al. JPGN 2018; 67: 561-3) explain why pureed fruit/food pouches can be detrimental for child health.  An easy-to-read editorial in NY Times discusses some of the same issues –Link: Rethinking Baby Food Pouches

Key points:

  • Pouches may interfere with learning to eat from a spoon.
  • Feeding infants “a variety of food textures and lumpy foods by spoon feeding and finger foods provides great opportunities for intensive reciprocal interaction between parent and infant”
  • These products generally have high energy density, high sugar content, and a very sweet taste and likely predispose towards bad food choices/selection as the child gets older.
  • Also, these food pouches may increase the risk of dental caries

Additional points from NY Times:

  • The popular pouches, introduced about a decade ago, now account for 25 percent of baby food sales in the United States, according to Nielsen’s Total Food View.
  • The features that make pouches so convenient, though — the smooth texture and squeeze packaging — have some experts concerned. They caution against relying on them too much, saying that they can be a gateway to bad long-term snacking habits and routine overeating
  • If given these pouches when irritable, children also run the risk of learning to associate sweet snacks with calming down, and to think of snacking in general as an activity to satisfy emotional rather than physiological needs.
  • “Feeding is truly a developmental process, just like learning to crawl, walk, run. We would never do anything to keep a child from crawling,” Ms. [Melanie] Potock [a feeding specialist] said. “Let’s not do anything that would stall them in the development of eating.”

Association and Causation: Early Life Risk Factors for Eosinophilic Esophagitis

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A recent case-control study (CP Witmer et al. JPGN 2018; 610-5) using the Military Health System Database examined 1410 cases of eosinophilic esophagitis (EoE) and matched them with 2820 controls; the study period was 2008-2015.

  • The authors found that early exposure to proton pump inhibitors (PPIs), histamine-2 receptors (H2RAs), and antibiotics were all associated with an increased risk of developing EoE with adjusted odds ratios of 2.73, 1.64, and 1.31.
  • In addition, among atopic problems, milk protein allergy had an adjusted odds ratio of 2.37 and eczema 1.97. –for developing EoE.

My take: This study does not determine whether the use of PPIs, H2RAs or antibiotics are involved in causation of EoE or whether patients with EoE simply receive these medications more frequently.  Nevertheless, the findings reinforce the idea that these medications should be used less frequently in infants.

Related blog posts:

Somewhere near Banff

Differential Microbiome Effects of Prebiotics and low FODMAPs

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A recent study (J-W Huaman et al. Gastroenterol 2018; 155: 1004-7) examined the effects of a prebiotic (Bimuno) and a low FODMAPs diet for the treatment of functional GI disorders and their effects on the microbiome.

This was a randomized controlled 4-week trial with a 2-week followup period.  Those who received the prebiotic (N=19) received a placebo diet (Mediterranean-type) and those who were randomized to a low FODMAP diet (n=21) were instructed to consume a placebo.  The prebiotic contained beat-galactooligosaccharide.

Key findings:

  • Both groups had significant reduction in GI symptoms, though low FODMAPs was the only treatment helpful for flatulence/borborygmi.
  • The symptom reduction persisted in the prebiotic group for the 2 -week follow-up period, whereas symptoms reappeared immediately in the low FODMAP group.
  • The two treatments had opposite effects on the intestinal microbiota –the prebiotic treatment led to an increase in bifidobacteria and a decrease in Bilophilia wadsworthia.

My take: (borrowed from editorial pg 960-2): This study “may indicate that the effect of the prebiotic is mediated through its effects on gut microbiota composition, whereas the effect of the low FODMAP diets is more related to the meal composition…than to its effects on gut microbiota composition.”

Related blog posts:

From two of the missions in San Antonio

 

 

 

 

Sex-Based Differences in Incidence of Inflammatory Bowel Disease

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Briefly noted: SC Shah, H Khalili et al. Gastroenterol 2018; 155: 1079-89.

This study evaluated pooled data with 207,600 incident cases of IBD from a population of 478 million. Key findings:

  • Female patients had lower a lower risk of Crohn’s disease during childhood until 10-14 years of age, but then a risk afterwards
  • For ulcerative colitis, there was a divergence in risk after 45 years of age, when men had a significantly higher incidence.

My take: the differences indicate that genetic factors (men with a Y chromosome and only one chromosome X) along with sex hormones play a role in the pathogenesis of IBD.

Graphs depict Female/Male Incidence Rate Ratio

AGREE proceedings: Briefly noted: ES Dellon, CA Liacouras, J Molina-Infante, GT Furuta et al. Gastroenterology 2018; 155: 1022-33.  This report provides updated recommendations from AGREE conference –which have been widely cited previously on this blog and elsewhere.  One of the remarkable features on this report is the fact that there are 64 authors (by my count) –thus reading the affiliations and the conflict of interest disclosures alone would take some time.

For a good review on this topic:

Adverse Childhood Experiences

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Recently, I attended the 17th Annual Donald Schaffner lecture.  This lecture honors the legacy of an outstanding surgeon who I had the opportunity to work with many years ago.  One of my partners, Dr. Jeff Lewis, has been instrumental in arranging these annual lectures.

This terrific lecture by Emory physician, Dr. Stan Sonu, focused on Adverse Childhood Experiences (ACEs).  While this has been a pervasive long-standing problem, there has been heightened interest in this topic following the shameful policy of promoting childhood separations at the U.S.-Mexico border.

This lecture explained how widespread the problem of ACEs is among children born in the U.S., even among the affluent.  Much of the lecture focused on the ACEs study which included a cohort of 17,000 –all of whom were insured and 75% were white and 75% were college educated.

Here are pictures of some of the slides -which explain the scope the problem and the consequences of ACEs:

The above slide provides the three take home points.

The slide above shows associations between ACEs and smoking drinking, and IV drug use. The slides below shows associations between ACEs and negative mental health outcomes,  chronic diseases, and poor work performance.

The slide above demonstrates that adverse health effects are increased even among 18-34 year olds. The slide below showed that learning problems are associated with ACEs as well; thus, the effects of ACEs start in childhood.

The slide above coincided with discussions (&other slides) of how toxic stress can result in physical changes to the brain.

The slide above (which is difficult to see)  indicates that while we see the health effects, we often are not seeing ACEs directly.

Dr. Sonu stated the single most protective factor was having a stable relationship with caregiver.

 

 

Liver Shorts November 2018

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J Ge et al. Hepatology 2018; 68: 1101-10.  This study reviewed liver donation offers between 2010 to 2014.  This study found that 5.6% of men (293/5202) and 6.2% of women (179/2899) received a pediatric donor as a first offer.  Women, but not men, who received a pediatric first offer had a lower risk of waitlist mortality than with those who received adult organ offers. The authors recommend that “offers of pediatric donor liver be prioritized to women, who are generally shorter stature, once alllocation to the entire…pediatric waitlist pool has occurred.”

CA Chapin et al. Hepatology 2018; 68: 1087-1100.  This study found that patients with indeterminate pediatric acute liver failure (iPALF) have a unique pattern of dense CD8+ T-cell infiltrate that is also perforin-positive adn CD103-positive.  These CD8+ cells are a biomarker for immune dysregulation. These CD8+ dense pattern was found in the 27 of 33 patients with iPALF; 3 had moderate and 3 had minimal staining pattern (per table 2).  The dense CD8+ pattern was seen in 3 of 9 with autoimmune hepatitis and in 1 of 14 with other liver diseases.

E-D Pfister et al. Liver Transplantation 2018; 24: 1186-98.  This study examined patient (n=338) and graft survival in the pediatric population (median age 14.0 years) with Wilson’s disease (1968-2013).  Overall, patient survival was 87% at 1 year, 84% at 5 years, and 81% at 10 years.  Though, the survival was much improved since 2009.

JA Bezzerra et al. Hepatology 2018; 68: 1163-73. This review summarized a research workshop (June 2017) focused on the clinical and research challenges for biliary atresia.

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