Images Only: EoE, Measles Outbreak, and Obesity Rate Disparities
Images Only: Health Disparity for Maternal Deaths and HCV Treatment
Fecal Microbiota Transplantation: How important is the BMI of the stool donor?
Currently fecal microbiota transplantation (FMT) “best practices” exclude obese stool donors based on a report of germ-free mice gaining weight after FMT from mice with obesity and based on a case report of an individual with 34 pound weight gain after FMT.
A recent report (M Fischer et al. Clin Gastroenterol Hepatol 2018; 16: 1351-3) suggests that the the BMI of the stool donor does not affect recipient weight after a single FMT procedure for C difficile infection.
This analysis included 173 patients with a mean age of 57 years. One group of 103 were from a randomized control trial; in this group, 66 (64%) received FMT from a normal weight (BMI 18-24.9) donor and 37 (36%) received FMT from an overweight (BMI 25-29.9) donor. Among an additional 70 individuals from an observational cohort, 25 received FMT from normal weight donor, 30 received FMT from overweight donor, and 15 received FMT from an obese donor.
Key finding:
- There was no significant difference in BMI among the FMT recipients up to 48 weeks after a single FMT. Based on data from Figure 1, patients who received FMT from normal weight donor had slightly higher mean weight gain at 48 weeks afterwards (not statistically-significant)
The authors caution that a prospective study is required to confirm these findings and in the interim, they recommend exclusion of obese/overweight FMT donors.
My take: There are plenty of willing stool donors –so who knows if this will ever be examined adequately. This study challenges the idea that FMT from an obese donor will result in recipient obesity, presumably via changes in the microbiome.
Related blog posts:
- Consensus Guidelines on FMT | gutsandgrowth
- Fecal Transplantation: “Frozen is as Good as Fresh” | gutsandgrowth
- Rejected! Most Stool is Not Good Enough for FMT | gutsandgrowth
- Clostridium difficile/Fecal Microbiota Transplantation … – gutsandgrowth
- Another Way of Preventing Recurrent Clostridium … – gutsandgrowth
- FMT in the “Real World”
Exclusive Enteral Nutrition for Crohn’s Disease -Less Effective in Those with Isolated Colonic Disease
A recent study (Y Xu. Clinical Nutrition 2018; https://doi.org/10.1016/j.clnu.2018.08.022) showed that exclusive enteral nutrition (EEN) is less effective in patient’s with Crohn’s disease with isolated colonic disease.
This was a retrospective study of 241 adults: 52 patients in the cCD (isolated colonic disease) group and 189 patients in the non-cCD group.
Key findings:
- “The rates of clinical remission differed between the two groups (cCD group: 51.9% versus non-cCD group: 68.3%, P = 0.029). Multivariate analyses indicated that isolated colonic involvement was associated with a reduced response to EEN (OR = 2.74; [CI] 95% = [1.2 –6.23], P = 0.016).”
- “Further analysis showed that even in patients who achieved clinical remission after EEN, inflammatory serum markers declined more slowly in the cCD group than in the non-cCD group, and the time to remission was longer in the cCD group.”
Related blog posts:
- Practical Advice on Enteral Nutrition | gutsandgrowth
- Head-to-Head: Enteral Nutrition vs. anti-TNF
- Gut Microbiome, Crohn’s Disease and Effect of Diet …
- The Search for a Dietary Culprit in IBD | gutsandgrowth
- Top Lecture: Enteral Nutrition for Crohn’s Disease …
- There is No Healthy Microbiome
- Why Does Enteral Nutrition Work for Crohn’s Disease? Is it due to the Microbiome?
This Makes Me Mad…Immigration Policy
When our government takes actions on behalf of our country, this reflects on all of our values. So, earlier this year I was disgusted and angry when I learned that as part of a ‘zero tolerance’ rule, young children were separated from their parents and placed in something akin to cages. For me, this is a stain on our country’s history that could be compared to other atrocities like the Tuskegee experiments and Japanese internment during WWII. While this policy was more short-lived, there are still children separated from their parents and for the children involved the consequences could be life-long. Sadly, our entire country is responsible because we elected this administration which adopted these policies.
Now, this administration which seems incapable of any shame, is planning more steps that should make decent persons upset. Additional threats to lawful immigrants are being devised (KM Perreira et al. NEJM 2018; 379: 901-3).
“Under current guidelines, persons labeled as potential public charges can be denied legal entry to the United States” and in some cases deported. Public-charge guidelines aim to keep immigrants from relying on public charges (eg. cash-assistance programs like welfare) for the first 5 years after admission to the U.S.
“The Trump administration is proposing sweeping changes to these [public-charge] guidelines.” One of these proposed expansions of public-charge determination is including enrollment for Obamacare, which is legally mandated and which can include subsidies. Another target is the Children’s Health Insurance Program. As a consequence of these guideline changes, instead of ~3% of lawful immigrants being considered as receiving a public charge, if adopted, this would increase to a range from 32% to 47%.
If these policies are adopted, this is likely to have a lot of adverse health consequences. Immigrants, including U.S.-born children, will be less likely to receive health care and more likely to be food insecure; 25% of U.S.-born children of immigrants currently receive SNAP (supplemental nutrition assistance program) benefits. Health consequences will affect millions and include an increase in low birth infants, increased infant mortality, and increased maternal morbidity.
For health care providers and institutions, implementation of these policies is likely to result in higher costs from uncompensated care.
In related commentaries (BL Grace et al. NEJM 2018; 379: 904-5, M Martin. NEJM 2018; 379: 906-7), the authors note the following points:
- “Current immigration policies are undermining trust in U.S institutions…and changing the way immigrants and refugees seek health care.” Many are worried that seeking health care could lead directly or indirectly (after providing information) to deportation
- “Even naturalized citizens fear that their status is no longer secure.”
- “I feel sad that my colleague’s 6-year-old patient has nightmares and urinary incontinence because she is terrified her parents will be deported. Sad that my patients fear coming to the hospital despite grave illness out of panic that someone will ask about their immigration status.”
My take: We are all accomplices (many unwitting) in the roll out of these detrimental policies that are now affecting lawful immigrants..
Related blog posts:
“If this was celiac, why didn’t it stop when she cut out gluten?”
Here’s a link to a well-described case report. Her Searing Gut Pain Suggested Celiac Disease. Why Didn’t Cutting Out Gluten Help?
This 57 year old with ‘presumptive’ celiac disease did not improve with a gluten-free diet. After an initial self-diagnosis and subsequently an endoscopy that also suggested celiac disease, she did not improve. While the doctors involved in her care had labeled her ‘noncompliant,’ it turns out she did NOT have celiac disease and improved after the right diagnosis (diagnosis noted at bottom of this post).
My take: There are several entities that can mimic celiac disease (even histologically), including Crohn’s disease, Autoimmune enteropathy, CTLA4 deficiency, and Whipple’s disease (the diagnosis in this case). When someone is not getting better, the diagnosis needs to be reconsidered.
Life & Death before Roe v Wade
A recent commentary describes the tragic outcome of one young nurse in 1968: A Remembrance of Life before Roe v. Wade
An excerpt: Why am I telling Jane’s story now? The lack of legal and safe abortion before the Roe v. Wade decision of 1973 killed and maimed thousands of young women.
Images Only: Combined 5-ASA/Biologics in Ulcerative Colitis, & Carbohydrate Intake and Health
Effects of Surgical Shunts on Liver Atrophy in Patients with Noncirrhotic Portal Vein Thrombosis
A recent study (AS Elnaggar et al. Liver Transplantation 2018; 24: 881-87; editorial 868-9) examine the effect of different types of surgical shunts in the setting of portal vein thrombosis (PVT). The authors examined surgical shunts from 1998-2011 in their institution (senior author: Jean Emond).
- 40 patients received “portal flow-preserving shunts”: 32 mesoportal and 8 selective splenorenal
- 24 received portal flow-diverting shunts (16 nonselective splenorenal and 8 mesocaval)
- Of these 64 patients, only 39 had preoperative and postoperative cross-sectional imaging. In addition, only 11 patients who had mesoportal shunt (7 children and 4 adults) had preoperative and postoperative cross-sectional imaging allowing for volume comparison.
Key finding:
- In patients receiving portal flow-preserving shunts (mainly mesoportal), this was associated with liver volume expansion (886 versus 1131 cm to the third), whereas diverting shunts were not.
The authors note that liver atrophy, especially in children, can have a “significant effect on cognitive function and somatic growth.” Thus, restoring portal flow may improve adverse effects that PVT has caused.
Limitations:
- Lack of validation of their formula to calculate liver volumes in the pediatric age group
- Relatively short follow-up:5.7 months in the portal-preserving group and 11 months in the other group
- Small numbers of patients..
Long-term followup of patients who have needed surgical shunts is needed. For mesoportal shunts, strictures have been noted in the hepatic end in 15% of patients.
My take: This study shows that portal blood flow, which was interrupted by PVT and restored by mesoportal (Rex) shunt, is important in maintaining liver mass. So, while all shunts may stop upper GI bleeding, mesoportal shunt is likely to improve other adverse effects of PVT.














